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Pathway Detail Page

Pathway name

Biosynthesis of Cortisone

Network of the pathway

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Reactions involved in the pathway

RXN01395

Pregnenolone+ Oxygen+ NADH+ Proton irreversible reaction arrow 17alpha-Hydroxypregnenolone+ Water+ NAD
Pregnenolone
Oxygen
NADH
Proton
  17alpha-Hydroxypregnenolone
Water
NAD

RXN00340

17alpha-Hydroxypregnenolone+ NAD reversible reaction arrow 17alpha-Hydroxyprogesterone+ NADH+ Proton
17alpha-Hydroxypregnenolone
NAD
  17alpha-Hydroxyprogesterone
NADH
Proton

RXN00256

17alpha-Hydroxypregnenolone+ NADP reversible reaction arrow 17alpha-Hydroxyprogesterone+ NADPH+ Proton
17alpha-Hydroxypregnenolone
NADP
  17alpha-Hydroxyprogesterone
NADPH
Proton

RXN00118

17alpha-Hydroxyprogesterone+ NADH+ Oxygen+ Proton irreversible reaction arrow 11-Deoxycortisol+ Water+ NAD
17alpha-Hydroxyprogesterone
NADH
Oxygen
Proton
  11-Deoxycortisol
Water
NAD

RXN00858

11-Deoxycortisol+ Oxygen+ Ferredoxin_(reduced) unknown reaction arrow Cortisol+ Water+ Ferredoxin_(oxidized)
11-Deoxycortisol
Oxygen
Ferredoxin_(reduced)
  Cortisol
Water
Ferredoxin_(oxidized)

RXN01021

11beta-Hydroxyprogesterone+ Oxygen+ NADH+ Proton irreversible reaction arrow 21-Deoxycortisol+ Water+ NAD
11beta-Hydroxyprogesterone
Oxygen
NADH
Proton
  21-Deoxycortisol
Water
NAD

RXN00856

21-Deoxycortisol+ Oxygen+ NADH+ Proton irreversible reaction arrow Cortisol+ Water+ NAD
21-Deoxycortisol
Oxygen
NADH
Proton
  Cortisol
Water
NAD

RXN01220

Cortisol+ NAD irreversible reaction arrow Cortisone+ NADH+ Proton
Cortisol
NAD
  Cortisone
NADH
Proton

RXN00800

Cortisol+ NADP irreversible reaction arrow Cortisone+ NADPH+ Proton
Cortisol
NADP
  Cortisone
NADPH
Proton